Gut leakage enhances sepsis susceptibility in iron-overloaded β-thalassemia mice through macrophage hyperinflammatory responses | Zendy

Peerapat Visitchanakun | Zendy; Wilasinee Saisorn | Zendy; Jutamas Wongphoom | Zendy; Piraya Chatthanathon | Zendy; Naraporn Somboonna | Zendy; Saovaros Svasti | Zendy; Suthat Fucharoen | Zendy; Asada Leelahavanichkul | Zendy

Open Access

Gut leakage enhances sepsis susceptibility in iron-overloaded β-thalassemia mice through macrophage hyperinflammatory responses

Author(s) -

Peerapat Visitchanakun,

Wilasinee Saisorn,

Jutamas Wongphoom,

Piraya Chatthanathon,

Naraporn Somboonna,

Saovaros Svasti,

Suthat Fucharoen,

Asada Leelahavanichkul

Publication year - 2020

Publication title -

ajp gastrointestinal and liver physiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.644

H-Index - 169

eISSN - 1522-1547

pISSN - 0193-1857

DOI - 10.1152/ajpgi.00337.2019

Subject(s) - thalassemia , sepsis , macrophage , immunology , medicine , biology , genetics , in vitro

Although the impact of iron accumulation in several organs of patients with thalassemia is well known, the adverse effect of iron accumulation in gut is not frequently mentioned. Here, we demonstrated iron-induced gut-permeability defect, impact of organismal molecules from gut translocation of, and macrophage functional defect upon the increased sepsis susceptibility in thalassemia mice.

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