Immune modulating effects of additional supplementation of estradiol combined with testosterone in murine testosterone-deficient NAFLD model | Zendy

Takuro Okamura | Zendy; Masahide Hamaguchi | Zendy; Ryo Bamba | Zendy; Hanako Nakajima | Zendy; Yuta Yoshimura | Zendy; Tomonori Kimura | Zendy; Kensuke Nishida | Zendy; Yoshitaka Hashimoto | Zendy; Takuya Fukuda | Zendy; Takafumi Senmaru | Zendy; Michiaki Fukui | Zendy

Open Access

Immune modulating effects of additional supplementation of estradiol combined with testosterone in murine testosterone-deficient NAFLD model

Author(s) -

Takuro Okamura,

Masahide Hamaguchi,

Ryo Bamba,

Hanako Nakajima,

Yuta Yoshimura,

Tomonori Kimura,

Kensuke Nishida,

Yoshitaka Hashimoto,

Takuya Fukuda,

Takafumi Senmaru,

Michiaki Fukui

Publication year - 2020

Publication title -

ajp gastrointestinal and liver physiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.644

H-Index - 169

eISSN - 1522-1547

pISSN - 0193-1857

DOI - 10.1152/ajpgi.00310.2019

Subject(s) - testosterone (patch) , nonalcoholic fatty liver disease , medicine , estrogen , endocrinology , immune system , menopause , fatty liver , disease , immunology

The progression of nonalcoholic fatty liver disease (NAFLD) is associated with testosterone deficiency. NAFLD patients generally do not respond to treatment with testosterone alone. In animal studies, treatment with testosterone and estrogen reduced the ratios of ILC2:CD45 and ILC3:CD45 and increased M2 macrophages in liver. Our study suggests, based on our immunological data, that a combination of estrogen and testosterone may be clinically relevant for the treatment of NAFLD in patients with male menopause.

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