Open AccessClC-2 and intestinal chloride secretion
Author(s) -
Carlos A. Flores
Publication year - 2016
Publication title -
ajp gastrointestinal and liver physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.644
H-Index - 169
eISSN - 1522-1547
pISSN - 0193-1857
DOI - 10.1152/ajpgi.00310.2016
Subject(s) - secretion , chloride channel , lubiprostone , chloride , apical membrane , chemistry , microbiology and biotechnology , crypt , biology , biochemistry , medicine , membrane , endocrinology , constipation , chronic constipation , organic chemistry
to the editor: Beyder and Farrugia ([1][1]) state in their recently published review that lubiprostone is an opener of ClC-2 chloride channels and that through that action it can ameliorate constipation, implying that ClC-2 would mediate chloride and therefore fluid secretion. Support for this claim
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