Functional role and therapeutic targeting of microRNAs in inflammatory bowel disease | Zendy

Artin Soroosh | Zendy; Μαρίνα Κουτσιούμπα | Zendy; Charalabos Pothoulakis | Zendy; Dimitrios Iliopoulos | Zendy

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Functional role and therapeutic targeting of microRNAs in inflammatory bowel disease

Author(s) -

Artin Soroosh,

Μαρίνα Κουτσιούμπα,

Charalabos Pothoulakis,

Dimitrios Iliopoulos

Publication year - 2017

Publication title -

ajp gastrointestinal and liver physiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.644

H-Index - 169

eISSN - 1522-1547

pISSN - 0193-1857

DOI - 10.1152/ajpgi.00268.2017

Subject(s) - inflammatory bowel disease , microrna , ulcerative colitis , disease , pathogenesis , medicine , epigenetics , crohn's disease , bioinformatics , immunology , inflammatory bowel diseases , biology , gene , genetics

Inflammatory bowel diseases (IBD) are chronic inflammatory gastrointestinal diseases, primarily consisting of ulcerative colitis and Crohn’s disease. The complex nature of the disease, as well as the limited therapeutic options characterized by low efficiency and major side effects, highlights the importance of developing novel strategies of therapeutic intervention in IBD. Susceptibility loci related to IBD are present only in a small percentage of IBD patients, implying that epigenetic modifications could influence the pathogenesis of the disease. MicroRNAs (miRNAs) are small noncoding RNAs that regulate multiple molecular pathways involved in IBD pathobiology. MiRNA inhibitors targeting the IBD-activated miRNAs could have therapeutic value for IBD patients. This review provides an overview of the recent advances in miRNA biology related to IBD pathogenesis and the pharmacological development of miRNA-based therapeutics.

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