Long-term trans-inhibition of the hepatitis B and D virus receptor NTCP by taurolithocholic acid | Zendy

Kira A. A. T. Lowjaga | Zendy; Michael Kirstgen | Zendy; Simon Müller | Zendy; Nora Goldmann | Zendy; Felix Lehmann | Zendy; Dieter Glebe | Zendy; Joachim Geyer | Zendy

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Long-term trans-inhibition of the hepatitis B and D virus receptor NTCP by taurolithocholic acid

Author(s) -

Kira A. A. T. Lowjaga,

Michael Kirstgen,

Simon Müller,

Nora Goldmann,

Felix Lehmann,

Dieter Glebe,

Joachim Geyer

Publication year - 2020

Publication title -

ajp gastrointestinal and liver physiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.644

H-Index - 169

eISSN - 1522-1547

pISSN - 0193-1857

DOI - 10.1152/ajpgi.00263.2020

Subject(s) - transporter , receptor , hepatitis b virus , virology , viral entry , bile acid , chemistry , biology , virus , biochemistry , gene , viral replication

The hepatic bile acid transporter NTCP is a high-affinity receptor for hepatitis B and D viruses. This study shows that TLC rapidly accumulates in NTCP-expressing hepatoma cells and mediates long-lasting trans-inhibition of NTCP’s transporter and receptor function via an intracellularly accessible domain, without substantially affecting its membrane expression. This domain is a promising novel NTCP target site for pharmacological long-acting HBV/HDV entry inhibitors.

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