Glucagon-like peptide 1 and glucose-dependent insulinotropic polypeptide stimulate release of substance P from TRPV1- and TRPA1-expressing sensory nerves | Zendy

Fahima Mayer | Zendy; Amanda L. Gunawan | Zendy; Patrick Tso | Zendy; Gregory W. Aponte | Zendy

Open Access

Glucagon-like peptide 1 and glucose-dependent insulinotropic polypeptide stimulate release of substance P from TRPV1- and TRPA1-expressing sensory nerves

Author(s) -

Fahima Mayer,

Amanda L. Gunawan,

Patrick Tso,

Gregory W. Aponte

Publication year - 2020

Publication title -

ajp gastrointestinal and liver physiology

Language(s) - English

Resource type - Journals

eISSN - 1522-1547

pISSN - 0193-1857

DOI - 10.1152/ajpgi.00189.2019

Subject(s) - trpv1 , sensory system , substance p , glucagon like peptide 1 , medicine , endocrinology , glucagon , peptide , chemistry , neuropeptide , receptor , neuroscience , biology , biochemistry , insulin , transient receptor potential channel , diabetes mellitus , type 2 diabetes

Glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) are secreted upon eating to lower blood sugar. GLP-1 and GIP were found to induce the secretion of substance P (SP) from cultured sensory nerves. SP enhances insulin secretion. Mesenteric lymphatic fluid (MLF) also stimulates sensory neurons in a diet-dependent manner. These studies identify new actions of GLP-1 and GIP as incretins and suggest a mechanism for sensory nerves to respond to diet through MLF.

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