Lipid mediators of liver injury in nonalcoholic fatty liver disease | Zendy

Suthat Liangpunsakul | Zendy; Naga Chalasani | Zendy

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Lipid mediators of liver injury in nonalcoholic fatty liver disease

Author(s) -

Suthat Liangpunsakul,

Naga Chalasani

Publication year - 2018

Publication title -

ajp gastrointestinal and liver physiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.644

H-Index - 169

eISSN - 1522-1547

pISSN - 0193-1857

DOI - 10.1152/ajpgi.00170.2018

Subject(s) - nonalcoholic fatty liver disease , cirrhosis , steatosis , nonalcoholic steatohepatitis , fatty liver , fibrosis , pathogenesis , medicine , disease , liver injury , steatohepatitis , liver disease , gastroenterology , bioinformatics , biology

Nonalcoholic fatty liver disease (NAFLD) comprises a spectrum of histopathological phenotypes ranging from simple steatosis to more severe liver disease associated with cell injury, including nonalcoholic steatohepatitis (NASH), advanced fibrosis, and cirrhosis. Only a subset of patients with NAFLD develop NASH from yet incompletely understood mechanisms. Emerging data suggest lipid species other than triglycerides as contributors to the pathogenesis of NASH. In this mini review, we focus on the recent data on the mechanisms of NASH, focusing on these lipid mediators and their potential as therapeutic targets in NASH.

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