The glial cell-line derived neurotrophic factor: a novel regulator of intestinal barrier function in health and disease | Zendy

Michael Meir | Zendy; Sven Flemming | Zendy; Natalie Burkard | Zendy; Johanna Wagner | Zendy; ChristophThomas Germer | Zendy; Nicolas Schlegel | Zendy

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The glial cell-line derived neurotrophic factor: a novel regulator of intestinal barrier function in health and disease

Author(s) -

Michael Meir,

Sven Flemming,

Natalie Burkard,

Johanna Wagner,

ChristophThomas Germer,

Nicolas Schlegel

Publication year - 2016

Publication title -

ajp gastrointestinal and liver physiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.644

H-Index - 169

eISSN - 1522-1547

pISSN - 0193-1857

DOI - 10.1152/ajpgi.00125.2016

Subject(s) - glial cell line derived neurotrophic factor , autocrine signalling , neurotrophic factors , barrier function , regulator , enteric nervous system , microbiology and biotechnology , inflammation , gdnf family of ligands , inflammatory bowel disease , biology , cancer research , immunology , cell culture , neuroscience , medicine , disease , receptor , biochemistry , genetics , gene

Regulation of the intestinal epithelial barrier is a differentiated process, which is profoundly deranged in inflammatory bowel diseases. Recent data provide evidence that the glial cell line-derived neurotrophic factor (GDNF) is critically involved in intestinal epithelial wound healing and barrier maturation and exerts antiapoptotic effects under certain conditions. Furthermore, not only the enteric nervous system, but also enterocytes synthesize GDNF in significant amounts, which points to a potential para- or autocrine signaling loop between enterocytes. Apart from direct effects of GDNF on enterocytes, an immunomodulatory role of this protein has been previously assumed because of a significant reduction of inflammation in a model of chronic inflammatory bowel disease after application of GDNF. In this review we summarize the current knowledge of GDNF on intestinal epithelial barrier regulation and discuss the novel role for GDNF as a regulator of intestinal barrier functions in health and disease.

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