5-HT4-mediated neuroprotection: a new therapeutic modality on the way? | Zendy

Michael D. Gershon | Zendy

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5-HT₄-mediated neuroprotection: a new therapeutic modality on the way?

Author(s) -

Michael D. Gershon

Publication year - 2016

Publication title -

ajp gastrointestinal and liver physiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.644

H-Index - 169

eISSN - 1522-1547

pISSN - 0193-1857

DOI - 10.1152/ajpgi.00120.2016

Subject(s) - neuroprotection , enteric nervous system , neuroscience , biology , myenteric plexus , paracrine signalling , inflammation , vasoactive intestinal peptide , microbiology and biotechnology , immunology , neuropeptide , biochemistry , immunohistochemistry , receptor

Bianco and colleagues show that prucalopride is an effective neuroprotective agent against oxidative stress. This work extends prior observations on 5-HT4-mediated neuroprotection and shows that a new treatment modality may soon be tested for efficacy against inflammatory bowel disease and neurodegenenerative disorders of the enteric nervous system.

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