hsa_circRNA_001587 upregulates SLC4A4 expression to inhibit migration, invasion, and angiogenesis of pancreatic cancer cells via binding to microRNA-223 | Zendy

Xiutian Zhang | Zendy; Peng Tan | Zendy; Yuan Zhuang | Zendy; Lei Du | Zendy

Open Access

hsa_circRNA_001587 upregulates SLC4A4 expression to inhibit migration, invasion, and angiogenesis of pancreatic cancer cells via binding to microRNA-223

Author(s) -

Xiutian Zhang,

Peng Tan,

Yuan Zhuang,

Lei Du

Publication year - 2020

Publication title -

ajp gastrointestinal and liver physiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.644

H-Index - 169

eISSN - 1522-1547

pISSN - 0193-1857

DOI - 10.1152/ajpgi.00118.2020

Subject(s) - microrna , pancreatic cancer , cancer research , angiogenesis , circular rna , chemistry , cancer cell , microbiology and biotechnology , biology , cancer , gene , biochemistry , genetics

Human circular (hsa_circ)RNA_001587 and solute carrier family 4 member 4 (SLC4A4) are poorly expressed, but microRNA (miR)-223 is overexpressed in pancreatic cancer (PC) cells. hsa_circRNA_001587 binds to miR-223. Overexpression of hsa_circRNA_001587 inhibits PC progression. Overexpression of miR-223 downregulates the expression of SLC4A4 and promotes PC cell growth. hsa_circRNA_001587 may be a potential target for PC treatment.

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