Glucocorticoids and serum- and glucocorticoid-inducible kinase 1 are potent regulators of CFTR in the native intestine: implications for stress-induced diarrhea | Zendy

Md. Kaimul Ahsan | Zendy; Leandra K. FigueroaHall | Zendy; Vanessa Baratta | Zendy; Rolando García-Milian | Zendy; TuKiet T. Lam | Zendy; Kazi Mirajul Hoque | Zendy; Pedro J. Salas | Zendy; Nadia A. Ameen | Zendy

Open Access

Glucocorticoids and serum- and glucocorticoid-inducible kinase 1 are potent regulators of CFTR in the native intestine: implications for stress-induced diarrhea

Author(s) -

Md. Kaimul Ahsan,

Leandra K. FigueroaHall,

Vanessa Baratta,

Rolando García-Milian,

TuKiet T. Lam,

Kazi Mirajul Hoque,

Pedro J. Salas,

Nadia A. Ameen

Publication year - 2020

Publication title -

ajp gastrointestinal and liver physiology

Language(s) - English

Resource type - Journals

eISSN - 1522-1547

pISSN - 0193-1857

DOI - 10.1152/ajpgi.00076.2020

Subject(s) - glucocorticoid , druggability , diarrhea , kinase , biology , endocrinology , medicine , microbiology and biotechnology , gene , biochemistry

This is the first study to examine the mechanisms of glucocorticoid, serum- and glucocorticoid-inducible kinase 1, and nongenomic kinase signaling of CFTR in the native intestine. We identified unique and druggable intestine-specific factors of the pathway that are targets for treating stress-induced diarrhea.

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