Open AccessPharmacological activation of TGR5 promotes intestinal growth via a GLP-2-dependent pathway in mice
Author(s) -
Jenna Elizabeth Hunt,
Anna Billeschou,
Johanne Agerlin Windeløv,
Bolette Hartmann,
Christoph Ullmer,
Jens J. Holst,
Hannelouise Kissow
Publication year - 2020
Publication title -
ajp gastrointestinal and liver physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.644
H-Index - 169
eISSN - 1522-1547
pISSN - 0193-1857
DOI - 10.1152/ajpgi.00062.2020
Subject(s) - g protein coupled bile acid receptor , pharmacology , chemistry , microbiology and biotechnology , medicine , biology , receptor
Using the specific Takeda G protein-receptor-5 (TGR5) agonist RO5527239 and GLP-2 receptor knockout mice, we show that activation of TGR5 led to the increase in colonic GLP-1 and GLP-2 concomitant with a GLP-2 dependent growth response in the proximal portion of the small intestine.
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