Dysregulation of redox pathways in liver fibrosis | Zendy

Natalie J. Török | Zendy

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Dysregulation of redox pathways in liver fibrosis

Author(s) -

Natalie J. Török

Publication year - 2016

Publication title -

ajp gastrointestinal and liver physiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.644

H-Index - 169

eISSN - 1522-1547

pISSN - 0193-1857

DOI - 10.1152/ajpgi.00050.2016

Subject(s) - reactive oxygen species , pathogenesis , signal transduction , oxidative stress , fibrosis , antioxidant , liver fibrosis , liver disease , microbiology and biotechnology , cell signaling , disease , biology , bioinformatics , medicine , immunology , pathology , biochemistry

Reactive oxygen species are implicated in physiological signaling and cell fate decisions. In chronic liver diseases persistent and increased production of oxidative radicals drives a fibrogenic response that is a common feature of disease progression. Despite our understanding the biology of the main prooxidant enzymes, their targets, and antioxidant mechanisms in the liver, there is still lack of knowledge concerning their precise role in the pathogenesis of fibrosis. This review will examine the role of physiological redox signaling in the liver, provide an overview on recent advances in prooxidant and antioxidant pathways that are dysregulated during fibrosis, and highlight possible novel treatment targets.

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