Open AccessIncreased postprandial nonesterified fatty acid efflux from adipose tissue in prediabetes is offset by enhanced dietary fatty acid adipose trapping
Author(s) -
Émilie Montastier,
Run Zhou Ye,
Christophe Noll,
Léandre Bouffard,
Mélanie Fortin,
Frédérique Frisch,
Serge Phoenix,
Brigitte Guérin,
Éric Turcotte,
Gary F. Lewis,
André C. Carpentier
Publication year - 2021
Publication title -
endocrinology and metabolism/american journal of physiology: endocrinology and metabolism
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.507
H-Index - 201
eISSN - 1522-1555
pISSN - 0193-1849
DOI - 10.1152/ajpendo.00619.2020
Subject(s) - adipose tissue , postprandial , lipolysis , endocrinology , medicine , fatty acid , chemistry , prediabetes , white adipose tissue , intracellular , biochemistry , biology , type 2 diabetes , diabetes mellitus
We found higher adipose tissue dietary fatty acid trapping, limiting spillover to lean organs, that in part offsets the increase in appearance rate of palmitate from intracellular lipolysis in prediabetes. These results point to the adaptive nature of adipose tissue trapping and dietary fatty acid spillover as a protective mechanism against excess obesity-related palmitate appearance rate from intracellular adipose tissue lipolysis.