Open AccessAccelerated developmental adipogenesis programs adipose tissue dysfunction and cardiometabolic risk in offspring born to dams with metabolic dysfunction
Author(s) -
Anna Mikolajczak,
Nada Sallam,
Radha Dutt Singh,
Taylor Scheidl,
Emma Walsh,
Sebastian Larion,
Carol Huang,
Jennifer A. Thompson
Publication year - 2021
Publication title -
endocrinology and metabolism/american journal of physiology: endocrinology and metabolism
Language(s) - English
Resource type - Journals
eISSN - 1522-1555
pISSN - 0193-1849
DOI - 10.1152/ajpendo.00229.2021
Subject(s) - adipogenesis , offspring , adipose tissue , endocrinology , medicine , obesity , metabolic syndrome , biology , pregnancy , genetics
This study reveals that accelerated adipogenesis during the perinatal window of adipose tissue development predisposes to later life hypertrophic adipocyte dysfunction, thereby compromising the buffering function of the subcutaneous depot.