The anterior gradient-2 interactome | Zendy

Frédéric Delom | Zendy; M. Aiman Mohtar | Zendy; Ted R. Hupp | Zendy; Delphine Fessart | Zendy

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The anterior gradient-2 interactome

Author(s) -

Frédéric Delom,

M. Aiman Mohtar,

Ted R. Hupp,

Delphine Fessart

Publication year - 2019

Publication title -

ajp cell physiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.432

H-Index - 181

eISSN - 1522-1563

pISSN - 0363-6143

DOI - 10.1152/ajpcell.00532.2018

Subject(s) - proteostasis , interactome , endoplasmic reticulum , protein disulfide isomerase , microbiology and biotechnology , biology , unfolded protein response , cell , computational biology , chemistry , biochemistry , gene

The anterior gradient-2 (AGR2) is an endoplasmic reticulum (ER)-resident protein belonging to the protein disulfide isomerase family that mediates the formation of disulfide bonds and assists the protein quality control in the ER. In addition to its role in proteostasis, extracellular AGR2 is responsible for various cellular effects in many types of cancer, including cell proliferation, survival, and metastasis. Various OMICs approaches have been used to identify AGR2 binding partners and to investigate the functions of AGR2 in the ER and outside the cell. Emerging data showed that AGR2 exists not only as monomer, but it can also form homodimeric structure and thus interact with different partners, yielding different biological outcomes. In this review, we summarize the AGR2 “interactome” and discuss the pathological and physiological role of such AGR2 interactions.

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