Keeping fibroblasts in suspense: TAZ-mediated signaling activates a context-dependent profibrotic phenotype. Focus on “TAZ activation drives fibroblast spheroid growth, expression of profibrotic paracrine signals, and context-dependent ECM gene expression” | Zendy

Bram Piersma | Zendy; Ruud A. Bank | Zendy

Open Access

Keeping fibroblasts in suspense: TAZ-mediated signaling activates a context-dependent profibrotic phenotype. Focus on “TAZ activation drives fibroblast spheroid growth, expression of profibrotic paracrine signals, and context-dependent ECM gene expression”

Author(s) -

Bram Piersma,

Ruud A. Bank

Publication year - 2017

Publication title -

ajp cell physiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.432

H-Index - 181

eISSN - 1522-1563

pISSN - 0363-6143

DOI - 10.1152/ajpcell.00362.2016

Subject(s) - paracrine signalling , microbiology and biotechnology , context (archaeology) , spheroid , phenotype , fibroblast , signal transduction , biology , chemistry , in vitro , genetics , gene , receptor , paleontology

fibrosis in vital organs causes significant morbidity and mortality worldwide. Although our understanding of the cellular and molecular mechanisms underlying fibrosis has grown tremendously over the last decades, effective treatments that halt, reverse, or prevent the pathological accumulation and

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