Orai1 and STIM1 in ER/PM junctions: roles in pancreatic cell function and dysfunction | Zendy

Aran Son | Zendy; Seonghee Park | Zendy; Dong Min Shin | Zendy; Shmuel Muallem | Zendy

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Orai1 and STIM1 in ER/PM junctions: roles in pancreatic cell function and dysfunction

Author(s) -

Aran Son,

Seonghee Park,

Dong Min Shin,

Shmuel Muallem

Publication year - 2016

Publication title -

ajp cell physiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.432

H-Index - 181

eISSN - 1522-1563

pISSN - 0363-6143

DOI - 10.1152/ajpcell.00349.2015

Subject(s) - endoplasmic reticulum , orai1 , microbiology and biotechnology , stim1 , calcium signaling , signal transduction , intracellular , cell signaling , chemistry , organelle , biology

Membrane contact sites (MCS) are critical junctions that form between the endoplasmic reticulum (ER) and membranes of various organelles, including the plasma membrane (PM). Signaling complexes, including mediators of Ca 2+ signaling, are assembled within MCS, such as the ER/PM junction. This is most evident in polarized epithelial cells, such as pancreatic cells. Core Ca 2+ signaling proteins cluster at the apical pole, the site of inositol 1,4,5-trisphosphate-mediated Ca 2+ release and Orai1/transient receptor potential canonical-mediated store-dependent Ca 2+ entry. Recent advances have characterized the proteins that tether the membranes at MCS and the role of these proteins in modulating physiological and pathological intracellular signaling. This review discusses recent advances in the characterization of Ca 2+ signaling at ER/PM junctions and the relation of these junctions to physiological and pathological Ca 2+ signaling in pancreatic acini.

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