Open AccessCooling skin cancer: menthol inhibits melanoma growth. Focus on “TRPM8 activation suppresses cellular viability in human melanoma”
Author(s) -
Andrzej Słomiński
Publication year - 2008
Publication title -
ajp cell physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.432
H-Index - 181
eISSN - 1522-1563
pISSN - 0363-6143
DOI - 10.1152/ajpcell.00312.2008
Subject(s) - melanoma , trpm8 , menthol , cancer research , viability assay , skin cancer , cancer , chemistry , medicine , biochemistry , apoptosis , receptor , organic chemistry , transient receptor potential channel , trpv1
yamamura and colleagues ([17][1]) report that melanoma cells express transient receptor potential melastatin subfamily member 8 (TRPM8) receptors and that their activation suppresses melanoma viability. This effect is mediated by menthol, and the mechanism of action involves the influx of
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