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yamamura and colleagues ([17][1]) report that melanoma cells express transient receptor potential melastatin subfamily member 8 (TRPM8) receptors and that their activation suppresses melanoma viability. This effect is mediated by menthol, and the mechanism of action involves the influx of

Cooling skin cancer: menthol inhibits melanoma growth. Focus on “TRPM8 activation suppresses cellular viability in human melanoma”