Serotonin receptors take the TRiPV4 highway in chronic hypoxic pulmonary hypertension. Focus on “TRPV4 channel contributes to serotonin-induced pulmonary vasoconstriction and the enhanced vascular reactivity in chronic hypoxic pulmonary hypertension” | Zendy

Scott Earley | Zendy; Normand Leblanc | Zendy

Open Access

Serotonin receptors take the TRiPV4 highway in chronic hypoxic pulmonary hypertension. Focus on “TRPV4 channel contributes to serotonin-induced pulmonary vasoconstriction and the enhanced vascular reactivity in chronic hypoxic pulmonary hypertension”

Author(s) -

Scott Earley,

Normand Leblanc

Publication year - 2013

Publication title -

ajp cell physiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.432

H-Index - 181

eISSN - 1522-1563

pISSN - 0363-6143

DOI - 10.1152/ajpcell.00211.2013

Subject(s) - hypoxic pulmonary vasoconstriction , serotonin , vasoconstriction , hypoxia (environmental) , pulmonary hypertension , cardiology , medicine , receptor , chemistry , oxygen , organic chemistry

pulmonary arterial hypertension (PAH) is a rare human disease displaying a very poor prognosis of survival. The chronic increase in pulmonary vascular resistance associated with PAH eventually leads to right ventricular hypertrophy and failure, and ultimately death. It is well accepted that the

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