Pyk2 contributes to reepithelialization by promoting MMP expression. Focus on “Delayed skin wound repair in proline-rich protein tyrosine kinase 2 knockout mice” | Zendy

Dana T. Graves | Zendy; Yingying Wu | Zendy; Mallikarjun Badadani | Zendy

Open Access

Pyk2 contributes to reepithelialization by promoting MMP expression. Focus on “Delayed skin wound repair in proline-rich protein tyrosine kinase 2 knockout mice”

Author(s) -

Dana T. Graves,

Yingying Wu,

Mallikarjun Badadani

Publication year - 2014

Publication title -

ajp cell physiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.432

H-Index - 181

eISSN - 1522-1563

pISSN - 0363-6143

DOI - 10.1152/ajpcell.00098.2014

Subject(s) - matrix metalloproteinase , knockout mouse , microbiology and biotechnology , tyrosine , tyrosine kinase , wound healing , receptor tyrosine kinase , protein expression , focus (optics) , tyrosine kinase 2 , protein tyrosine phosphatase , cancer research , platelet derived growth factor receptor , biology , medicine , kinase , signal transduction , chemistry , immunology , biochemistry , receptor , gene , physics , growth factor , optics

matrix metalloproteinases (MMPs) play an important role in wound healing (reviewed in Ref. [5][1]). In the skin, the hemidesmosome attachment between keratinocytes and basement membrane is disrupted by MMP activity, so that keratinocytes are released to migrate under the wound matrix and contact the

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