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the addition of a single phosphate group to a protein can cause dramatic and varied changes in its function: it can change an ion channel's open probability ([31][1]), trigger the activation of an entire signaling cascade ([17][2]), or cause a protein to translocate to the cell surface ([30][3]).

american journal of physiology. cell physiology

<i>Beyond translation: the renal phosphate census.</i> Focus on “Large-scale phosphoproteomic analysis of membrane proteins in renal proximal and distal tubule”

Beyond translation: the renal phosphate census. Focus on “Large-scale phosphoproteomic analysis of membrane proteins in renal proximal and distal tubule”