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PurposeTo perform a proof-of-concept study to investigate the clinical utility of perfusion maps derived from convolutional neural networks (CNNs) for the workup of patients with acute ischemic stroke presenting with a large vessel occlusion.Materials and MethodsData on endovascularly treated patients with acute ischemic stroke (n = 151; median age, 68 years [interquartile range, 59-75 years]; 82 of 151 [54.3%] women) were retrospectively extracted from a single-center institutional prospective registry (between January 2011 and December 2015). Dynamic susceptibility perfusion imaging data were processed by applying a commercially available reference method and in parallel by a recently proposed CNN method to automatically infer time to maximum of the tissue residue function (Tmax) perfusion maps. The outputs were compared by using quantitative markers of tissue at risk derived from manual segmentations of perfusion lesions from two expert raters.ResultsStrong correlations of lesion volumes (Tmax > 4 seconds, > 6 seconds, and > 8 seconds; R = 0.865-0.914; P < .001) and good spatial overlap of respective lesion segmentations (Dice coefficients, 0.70-0.85) between the CNN method and reference output were observed. Eligibility for late-window reperfusion treatment was feasible with use of the CNN method, with complete interrater agreement for the CNN method (Cohen κ = 1; P < .001), although slight discrepancies compared with the reference-based output were observed (Cohen κ = 0.609-0.64; P < .001). The CNN method tended to underestimate smaller lesion volumes, leading to a disagreement between the CNN and reference method in five of 45 patients (9%).ConclusionCompared with standard deconvolution-based processing of raw perfusion data, automatic CNN-derived Tmax perfusion maps can be applied to patients who have acute ischemic large vessel occlusion stroke, with similar clinical utility.© RSNA, 2019Supplemental material is available for this article.

Neural Network–derived Perfusion Maps for the Assessment of Lesions in Patients with Acute Ischemic Stroke