Open AccessGastrointestinal Stromal Tumor
Author(s) -
Fitriani Lumongga
Publication year - 2003
Publication title -
radiographics
Language(s) - English
Resource type - Journals
eISSN - 1527-1323
pISSN - 0271-5333
DOI - 10.1148/rg.232035901
Subject(s) - stromal tumor , stromal cell , medicine
Most gastrointestinal stromal tumors (GISTs) harbor a gain-of-function mutation in the Kit receptor. GIST patients treated withthe tyrosine kinase inhibitor imatinib frequently develop imatinibresistance as a result of second-site Kit mutations. To investigatetheconsequencesofsecond-siteKitmutationsonGISTdevelopmentand imatinib sensitivity, we engineered a mouse model carrying inthe endogenous Kit locus both the Kit
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