Open AccessEvaluation of Breast Tumor Response to Neoadjuvant Chemotherapy with Tomographic Diffuse Optical Spectroscopy: Case Studies of Tumor Region-of-Interest Changes
Author(s) -
Shudong Jiang,
Brian W. Pogue,
Colin M. Carpenter,
Steven P. Poplack,
Wendy A. Wells,
Christine Kogel,
Jorge Forero,
Lori Muffly,
Gary N. Schwartz,
Keith D. Paulsen,
Peter A. Kaufman
Publication year - 2009
Publication title -
radiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.118
H-Index - 295
eISSN - 1527-1315
pISSN - 0033-8419
DOI - 10.1148/radiol.2522081202
Subject(s) - medicine , breast cancer , nuclear medicine , response evaluation criteria in solid tumors , institutional review board , receiver operating characteristic , complete response , region of interest , radiology , chemotherapy , cancer , surgery , progressive disease
To evaluate two methods of summarizing tomographic diffuse optical spectroscopic (DOS) data through region-of-interest (ROI) analysis to differentiate complete from incomplete responses in patients with locally advanced breast cancer undergoing neoadjuvant treatment and to estimate the standard deviations of these methods for power analysis of larger study designs in the future.