Open AccessEmbryonic Stem Cell Grafting in Normal and Infarcted Myocardium: Serial Assessment with MR Imaging and PET Dual Detection
Author(s) -
Hui Qiao,
Hualei Zhang,
Yuanjie Zheng,
Datta E. Ponde,
Dayong Shen,
Fabao Gao,
Ashley B. Bakken,
Alexander Schmitz,
Hank F. Kung,
Victor A. Ferrari,
Rong Zhou
Publication year - 2009
Publication title -
radiology
Language(s) - English
Resource type - Journals
eISSN - 1527-1315
pISSN - 0033-8419
DOI - 10.1148/radiol.2503080205
Subject(s) - medicine , embryonic stem cell , ejection fraction , magnetic resonance imaging , dapi , cardiac function curve , pathology , nuclear medicine , staining , heart failure , radiology , biology , biochemistry , gene
To use magnetic resonance (MR) imaging and positron emission tomography (PET) dual detection of cardiac-grafted embryonic stem cells (ESCs) to examine (a) survival and proliferation of ESCs in normal and infarcted myocardium, (b) host macrophage versus grafted ESC contribution to serial MR imaging signal over time, and (c) cardiac function associated with the formation of grafts and whether improvement in cardiac function is related to cardiac differentiation of ESCs.