Open AccessChronic Obstructive Pulmonary Disease: Lobar Analysis with Hyperpolarized 129Xe MR Imaging
Author(s) -
Tahreema Matin,
Najib M. Rahman,
Annabel H. Nickol,
Mitchell Chen,
Xiaojun Xu,
Neil J. Stewart,
Tom Doel,
Vicente Grau,
Jim M. Wild,
Fergus Gleeson
Publication year - 2017
Publication title -
radiology
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 3.118
H-Index - 295
eISSN - 1527-1315
pISSN - 0033-8419
DOI - 10.1148/radiol.2016152299
Subject(s) - medicine , copd , nuclear medicine , effective diffusion coefficient , dlco , magnetic resonance imaging , lung , lung volumes , diffusion mri , radiology , pulmonary function testing , respiratory disease , diffusing capacity , lung function
Purpose To compare lobar ventilation and apparent diffusion coefficient (ADC) values obtained with hyperpolarized xenon 129 ( 129 Xe) magnetic resonance (MR) imaging to quantitative computed tomography (CT) metrics on a lobar basis and pulmonary function test (PFT) results on a whole-lung basis in patients with chronic obstructive pulmonary disease (COPD). Materials and Methods The study was approved by the National Research Ethics Service Committee; written informed consent was obtained from all patients. Twenty-two patients with COPD (Global Initiative for Chronic Obstructive Lung Disease stage II-IV) underwent hyperpolarized 129 Xe MR imaging at 1.5 T, quantitative CT, and PFTs. Whole-lung and lobar 129 Xe MR imaging parameters were obtained by using automated segmentation of multisection hyperpolarized 129 Xe MR ventilation images and hyperpolarized 129 Xe MR diffusion-weighted images after coregistration to CT scans. Whole-lung and lobar quantitative CT-derived metrics for emphysema and bronchial wall thickness were calculated. Pearson correlation coefficients were used to evaluate the relationship between imaging measures and PFT results. Results Percentage ventilated volume and average ADC at lobar 129 Xe MR imaging showed correlation with percentage emphysema at lobar quantitative CT (r = -0.32, P < .001 and r = 0.75, P < .0001, respectively). The average ADC at whole-lung 129 Xe MR imaging showed moderate correlation with PFT results (percentage predicted transfer factor of the lung for carbon monoxide [Tlco]: r = -0.61, P < .005) and percentage predicted functional residual capacity (r = 0.47, P < .05). Whole-lung quantitative CT percentage emphysema also showed statistically significant correlation with percentage predicted Tlco (r = -0.65, P < .005). Conclusion Lobar ventilation and ADC values obtained from hyperpolarized 129 Xe MR imaging demonstrated correlation with quantitative CT percentage emphysema on a lobar basis and with PFT results on a whole-lung basis. © RSNA, 2016.