Open AccessIs the Relationship between Cortical and White Matter Pathologic Changes in Multiple Sclerosis Spatially Specific? A Multimodal 7-T and 3-T MR Imaging Study with Surface and Tract-based Analysis
Author(s) -
Céline Louapre,
Sindhuja T. Govindarajan,
Costanza Giannì,
Julien CohenAdad,
Michael D. Gregory,
A. Scott Nielsen,
Nancy Madigan,
Jacob Sloane,
Revere P. Kinkel,
Caterina Mainero
Publication year - 2016
Publication title -
radiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.118
H-Index - 295
eISSN - 1527-1315
pISSN - 0033-8419
DOI - 10.1148/radiol.2015150486
Subject(s) - white matter , diffusion mri , cortex (anatomy) , medicine , cingulum (brain) , fractional anisotropy , corticospinal tract , neuroscience , pyramidal tracts , magnetic resonance imaging , anatomy , pathology , psychology , radiology
To investigate in vivo the spatial specificity of the interdependence between intracortical and white matter (WM) pathologic changes as function of cortical depth and distance from the cortex in multiple sclerosis (MS), and their independent contribution to physical and cognitive disability.