Open AccessMultiple Sclerosis: Myeloperoxidase Immunoradiology Improves Detection of Acute and Chronic Disease in Experimental Model
Author(s) -
Benjamin Pulli,
Lionel Buré,
Gregory R. Wojtkiewicz,
Yoshiko Iwamoto,
Muhammad Ali,
Dan Li,
Stefan Schob,
Kevin Hsieh,
Andréas H. Jacobs,
John W. Chen
Publication year - 2015
Publication title -
radiology
Language(s) - English
Resource type - Journals
eISSN - 1527-1315
pISSN - 0033-8419
DOI - 10.1148/radiol.14141495
Subject(s) - myeloperoxidase , medicine , subclinical infection , experimental autoimmune encephalomyelitis , pathology , proinflammatory cytokine , multiple sclerosis , magnetic resonance imaging , infiltration (hvac) , immune system , immunology , gastroenterology , inflammation , radiology , thermodynamics , physics
To test if MPO-Gd, a gadolinium-based magnetic resonance (MR) imaging probe that is sensitive and specific for the proinflammatory and oxidative enzyme myeloperoxidase (MPO), which is secreted by certain inflammatory cells, is more sensitive than diethylenetriaminepentaacetic acid (DTPA)-Gd in revealing early subclinical and chronic disease activity in the brain in experimental autoimmune encephalomyelitis (EAE), a mouse model of multiple sclerosis.