Open AccessAccuracy of MR Imaging–estimated Proton Density Fat Fraction for Classification of Dichotomized Histologic Steatosis Grades in Nonalcoholic Fatty Liver Disease
Author(s) -
An Tang,
Ajinkya Desai,
Gavin Hamilton,
Tanya Wolfson,
Anthony Gamst,
Jessica Lam,
Lisa Clark,
Jonathan Hooker,
Tanya A. Chavez,
Brandon Ang,
Michael S. Middleton,
Michael R. Peterson,
Rohit Loomba,
Claude B. Sirlin
Publication year - 2015
Publication title -
radiology
Language(s) - English
Resource type - Journals
eISSN - 1527-1315
pISSN - 0033-8419
DOI - 10.1148/radiol.14140754
Subject(s) - medicine , nonalcoholic fatty liver disease , steatosis , magnetic resonance imaging , confidence interval , fatty liver , prospective cohort study , nuclear medicine , radiology , disease
To evaluate the diagnostic performance of previously proposed high-specificity magnetic resonance (MR) imaging-estimated proton density fat fraction (PDFF) thresholds for diagnosis of steatosis grade 1 or higher (PDFF threshold of 6.4%), grade 2 or higher (PDFF threshold of 17.4%), and grade 3 (PDFF threshold of 22.1%) by using histologic findings as a reference in an independent cohort of adults known to have or suspected of having nonalcoholic fatty liver disease (NAFLD).