Open AccessEstablishing the Lysine-rich Protein CEST Reporter Gene as a CEST MR Imaging Detector for Oncolytic Virotherapy
Author(s) -
Christian T. Farrar,
Jason S. Buhrman,
Guanshu Liu,
Anne Kleijn,
Martine L.M. Lamfers,
Michael T. McMahon,
Assaf A. Gilad,
Giulia Fulci
Publication year - 2015
Publication title -
radiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.118
H-Index - 295
eISSN - 1527-1315
pISSN - 0033-8419
DOI - 10.1148/radiol.14140251
Subject(s) - oncolytic virus , in vivo , medicine , herpes simplex virus , magnetic resonance imaging , virus , nuclear medicine , pathology , virology , biology , radiology , microbiology and biotechnology
To (a) evaluate whether the lysine-rich protein (LRP) magnetic resonance (MR) imaging reporter gene can be engineered into G47Δ, a herpes simplex-derived oncolytic virus that is currently being tested in clinical trials, without disrupting its therapeutic effectiveness and (b) establish the ability of chemical exchange saturation transfer (CEST) MR imaging to demonstrate G47Δ-LRP.