Hedgehog Signaling and Steroidogenesis | Zendy

Isabella Finco | Zendy; Christopher R. LaPensee | Zendy; Kenneth T. Krill | Zendy; Gary D. Hammer | Zendy

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Hedgehog Signaling and Steroidogenesis

Author(s) -

Isabella Finco,

Christopher R. LaPensee,

Kenneth T. Krill,

Gary D. Hammer

Publication year - 2015

Publication title -

annual review of physiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 10.475

H-Index - 207

eISSN - 1545-1585

pISSN - 0066-4278

DOI - 10.1146/annurev-physiol-061214-111754

Subject(s) - hedgehog , hedgehog signaling pathway , biology , signal transduction , cholesterol side chain cleavage enzyme , endocrine system , microbiology and biotechnology , adrenal cortex , signalling pathways , ovary , endocrinology , neuroscience , hormone , cytochrome p450 , metabolism

Since its discovery nearly 30 years ago, the Hedgehog (Hh) signaling pathway has been shown to be pivotal in many developmental and pathophysiological processes in several steroidogenic tissues, including the testis, ovary, adrenal cortex, and placenta. New evidence links the evolutionarily conserved Hh pathway to the steroidogenic organs, demonstrating how Hh signaling can influence their development and homeostasis and can act in concert with steroids to mediate physiological functions. In this review, we highlight the role of the components of the Hh signaling pathway in steroidogenesis of endocrine tissues.

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