Open AccessInduced Pluripotent Stem Cells for Regenerative Medicine
Author(s) -
Karen K. Hirschi,
Song Li,
Krishnendu Roy
Publication year - 2014
Publication title -
annual review of biomedical engineering
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.142
H-Index - 133
eISSN - 1545-4274
pISSN - 1523-9829
DOI - 10.1146/annurev-bioeng-071813-105108
Subject(s) - reprogramming , regenerative medicine , induced pluripotent stem cell , stem cell , biology , drug discovery , somatic cell , directed differentiation , cellular differentiation , microbiology and biotechnology , neuroscience , embryonic stem cell , computational biology , cell , bioinformatics , genetics , gene
With the discovery of induced pluripotent stem (iPS) cells, it is now possible to convert differentiated somatic cells into multipotent stem cells that have the capacity to generate all cell types of adult tissues. Thus, there is a wide variety of applications for this technology, including regenerative medicine, in vitro disease modeling, and drug screening/discovery. Although biological and biochemical techniques have been well established for cell reprogramming, bioengineering technologies offer novel tools for the reprogramming, expansion, isolation, and differentiation of iPS cells. In this article, we review these bioengineering approaches for the derivation and manipulation of iPS cells and focus on their relevance to regenerative medicine.