Response to Invasion by Antigens and Effects of Threshold in an Immune Network Dynamical System Model with a Small Number of Degrees of Freedom | Zendy

S. Itaya | Zendy; T. Uezu | Zendy

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Response to Invasion by Antigens and Effects of Threshold in an Immune Network Dynamical System Model with a Small Number of Degrees of Freedom

Author(s) -

S. Itaya,

T. Uezu

Publication year - 2002

Publication title -

progress of theoretical physics

Language(s) - English

Resource type - Journals

eISSN - 1347-4081

pISSN - 0033-068X

DOI - 10.1143/ptp.107.827

Subject(s) - physics , perturbation (astronomy) , immune system , antigen , stability (learning theory) , control theory (sociology) , biology , quantum mechanics , immunology , computer science , control (management) , machine learning , artificial intelligence

We study a dynamical system model of an idiotypic immune network with a smallnumber of degrees of freedom, mainly focusing on the effect of a thresholdabove which antibodies can recognise antibodies. The response of the system toinvasions by antigens is investigated in the both models with and without thethreshold and it turns out that the system changes in a desirable direction formoderate magnitude of perturbation. direction for moderate magnitude ofperturbation. Also, the propagation of disturbance by an antigen isinvestigated in the system of one-dimensionally connected basic units takingthe closed 3-clone system as a unit, and it is clarified that the threshold ofthe system has effects to enhance the stability of the network and to localisethe immune response.Comment: 6 pages, 6 figures. Submitted to Prog. Theor. Phy

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