Molecular Resolution Imaging of Protein Molecules in Liquid Using Frequency Modulation Atomic Force Microscopy | Zendy

Hirofumi Yamada | Zendy; Kei Kobayashi | Zendy; Takeshi Fukuma | Zendy; Yoshiki Hirata | Zendy; Teruyuki Kajita | Zendy; Kazumi Matsushige | Zendy

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Molecular Resolution Imaging of Protein Molecules in Liquid Using Frequency Modulation Atomic Force Microscopy

Author(s) -

Hirofumi Yamada,

Kei Kobayashi,

Takeshi Fukuma,

Yoshiki Hirata,

Teruyuki Kajita,

Kazumi Matsushige

Publication year - 2009

Publication title -

applied physics express

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.911

H-Index - 94

eISSN - 1882-0786

pISSN - 1882-0778

DOI - 10.1143/apex.2.095007

Subject(s) - bacteriorhodopsin , atomic force microscopy , frequency modulation , microscopy , resolution (logic) , deflection (physics) , materials science , mica , molecule , optics , chemistry , membrane , nanotechnology , physics , computer network , biochemistry , organic chemistry , bandwidth (computing) , artificial intelligence , computer science , composite material

We demonstrated molecular resolution imaging of biological samples such as bacteriorhodopsin protein molecules in purple membrane and isolated chaperonin (GroEL) protein molecules, both adsorbed on mica using frequency modulation atomic force microscope (FM-AFM) in liquid. We also showed that the frequency noise of FM-AFM in liquid can be greatly reduced by the reduction of the noise-equivalent deflection of an optical beam deflection sensor. © 2009 The Japan Society of Applied Physics

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