Open AccessDevelopment and implementation of incident response near-infrared models for analyzing contaminated medicines containing diethylene glycol solvent
Author(s) -
Yin Liang,
Zhang Xue-bo,
Xiaodong Li,
Jin Shao-hong
Publication year - 2014
Publication title -
journal of innovative optical health sciences/journal of innovation in optical health science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.421
H-Index - 24
eISSN - 1793-5458
pISSN - 1793-7205
DOI - 10.1142/s1793545814500357
Subject(s) - diethylene glycol , solvent , contamination , ethylene glycol , distilled water , raw material , chromatography , materials science , chemistry , organic chemistry , ecology , biology
Samples of preparations contaminated by diethylene glycol (DEG), diethylene glycol raw materials and laboratory prepared solutions were measured to get NIR spectra. Then the identification models were developed using the collected spectra and the spectra of distilled water, propylene glycol and the preparations without diethylene glycol. Besides, the quantification model was also established for determining the concentration of diethylene glycol in the preparations. Validation results show the identification and quantification models have ideal prediction performance. The emergency NIR models are rapid, easy to use and accurate, and can be implemented for identifying diethylene glycol raw material, screening the preparations contaminated by diethylene glycol in the markets and analyzing the concentrations of DEG