The application of extended modified Lambert Beer model for measurement of blood carboxyhemoglobin and oxyhemoglobin saturation | Zendy

Audrey Huong | Zendy; Xavier Ngu | Zendy

Open Access

The application of extended modified Lambert Beer model for measurement of blood carboxyhemoglobin and oxyhemoglobin saturation

Author(s) -

Audrey Huong,

Xavier Ngu

Publication year - 2014

Publication title -

journal of innovative optical health sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.421

H-Index - 24

eISSN - 1793-5458

pISSN - 1793-7205

DOI - 10.1142/s1793545814500266

Subject(s) - carboxyhemoglobin , beer–lambert law , saturation (graph theory) , attenuation , monte carlo method , hemoglobin , absorption (acoustics) , carbon monoxide poisoning , chemistry , analytical chemistry (journal) , carbon monoxide , materials science , optics , mathematics , chromatography , poison control , statistics , physics , medicine , environmental health , combinatorics , catalysis , biochemistry

This work presents the use of extended Modified Lambert Beer (MLB) model for accurate andcontinuous monitoring of percent blood carboxyhemoglobin (COHb) (SCO) and oxyhemoglobin(OxyHb) saturation (SO2) via a ¯tting procedure. This quanti¯cation technique is based on theabsorption characteristics of hemoglobin derivatives in the wavelength range of 520–600 nm togive the best estimates of the required parameters. A comparison of the performance of thedeveloped model and MLB law is made using attenuation data from Monte Carlo simulations fora two-layered skin model. The results revealed a lower mean absolute error of 0:4% in the valuesestimated by the developed model as compared to 10% that is given by the MLB law. This studyshowed that the discussed approach is able to provide consistent and accurate measurement ofblood SO2 and SCO across different skin pigmentations suggesting that it may potentially be usedas an alternative means for clinical diagnosis of carbon monoxide (CO) poisoning

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