Étude de l'annélation à partir de dérivés dibromomés-1,4 et -1,5 en présence de carbanions | Zendy

P. Cane | Zendy; Josée Plamondon | Zendy

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Étude de l'annélation à partir de dérivés dibromomés-1,4 et -1,5 en présence de carbanions

Author(s) -

P. Cane,

Josée Plamondon

Publication year - 1989

Publication title -

canadian journal of chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.323

H-Index - 68

eISSN - 1480-3291

pISSN - 0008-4042

DOI - 10.1139/v89-084

Subject(s) - chemistry , carbanion , decarboxylation , stereoselectivity , intramolecular force , medicinal chemistry , carbon fibers , stereochemistry , organic chemistry , catalysis , materials science , composite number , composite material

Primary–secondary dibromides have been prepared from the corresponding diols and used with carbon acids to prepare 1,2-disubstituted cyclic compounds. With unsymmetrical carbon acid in presence of NaH in DME, a high diastereoselection of the trans isomer is observed. Factors that affect the stereoselectivity are proposed. Keywords: intramolecular S N 2, decarboxylation, 2-alkylcycloalkanecarboxylic acids, 1-alkylindan-2-carboxylic acids.

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