Open AccessThe structure of the benzene–maleimide photosynthetic product (mitindomide)
Author(s) -
George R. Pettit,
Kenneth D. Paull,
Cherry L. Herald,
Delbert L. Herald,
Joseph R. Riden
Publication year - 1983
Publication title -
canadian journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.323
H-Index - 68
eISSN - 1480-3291
pISSN - 0008-4042
DOI - 10.1139/v83-397
Subject(s) - imide , maleimide , chemistry , maleic anhydride , benzene , crystal structure , amide , polymer chemistry , photochemistry , organic chemistry , polymer , copolymer
The photochemical reaction between benzene and maleic anhydride or benzene and maleimide affords respectively anhydride 6a and imide 6b. Unequivocal structures 6a and 6b were assigned on the basis of an X-ray crystal structure determination of amide 5 derived from imide 6b. Because of pronounced activity (e.g., PS T/C 206 at 50 mg/kg) against several of the U.S. National Cancer Institute's key experimental tumor systems, imide 6b has been designated mitindomide and is being prepared for eventual clinical trial.