Xanthocyclines: 5-oxaanthracyclines (7,8,9,10-tetrahydrobenzo[b]xanthen-12-one) | Zendy

James L. Charlton | Zendy; Vilayat A. Sayeed | Zendy; G. N. LYPKA | Zendy

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Xanthocyclines: 5-oxaanthracyclines (7,8,9,10-tetrahydrobenzo[b]xanthen-12-one)

Author(s) -

James L. Charlton,

Vilayat A. Sayeed,

G. N. LYPKA

Publication year - 1982

Publication title -

canadian journal of chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.323

H-Index - 68

eISSN - 1480-3291

pISSN - 0008-4042

DOI - 10.1139/v82-281

Subject(s) - chemistry , daunorubicin , cardiotoxicity , anthracycline , stereochemistry , antibiotics , combinatorial chemistry , pharmacology , organic chemistry , biochemistry , leukemia , toxicity , medicine , cancer , breast cancer

The anthracycline antibiotics daunorubicin and adriamycin are potent antitumor agents. It has recently been suggested that 5-oxaanthracycline analogs of these compounds might show reduced cardiotoxicity, a property that limits the clinical use of the anthracyclines. In this paper we describe the condensation–cyclization reactions of 2-methylchromone-3-carboxylate with cyclohexanones, a reaction that leads ultimately to the xanthocycline skeleton.

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