A synthetic approach to resistomycin | Zendy

John F. Kingston | Zendy; Larry Weiler | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

A synthetic approach to resistomycin

Author(s) -

John F. Kingston,

Larry Weiler

Publication year - 1977

Publication title -

canadian journal of chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.323

H-Index - 68

eISSN - 1480-3291

pISSN - 0008-4042

DOI - 10.1139/v77-109

Subject(s) - chemistry , aldol condensation , acetophenone , condensation , naphthalene , combinatorial chemistry , organic chemistry , catalysis , computational chemistry , physics , thermodynamics

An outline of a synthetic route to the antibiotic resistomycin is presented. We report the successful construction of an intermediate containing all of the carbon atoms in resistomycin with requisite functionalities. The key steps involved an aldol type condensation of the dianion from 2,4,6-trimethoxybenzoylacetone and a suitable acetophenone. This was followed by a novel acid-catalyzed cyclization–condensation to form the naphthalene intermediate required in our scheme.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research