Open AccessC-Acetylation of Ketones
Author(s) -
Stuart N. Huckin,
Larry Weiler
Publication year - 1974
Publication title -
canadian journal of chemistry
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 0.323
H-Index - 68
eISSN - 1480-3291
pISSN - 0008-4042
DOI - 10.1139/v74-210
Subject(s) - methyllithium , chemistry , acylation , acetylation , ketone , yield (engineering) , organic chemistry , simple (philosophy) , action (physics) , medicinal chemistry , catalysis , philosophy , biochemistry , materials science , physics , epistemology , quantum mechanics , metallurgy , gene
The action of 2 equiv. of methyllithium on the monoanion of simple β-keto esters gives the β-diketone in good yield. This represents a facile and new method to achieve the C-acylation of a ketone.