Open AccessSynthesis of 2′-(N′-bis(2-chloroethyl)glycyltryptophyl)emetine and related peptides
Author(s) -
George R. Pettit,
Surendra K. Gupta
Publication year - 1967
Publication title -
canadian journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.323
H-Index - 68
eISSN - 1480-3291
pISSN - 0008-4042
DOI - 10.1139/v67-253
Subject(s) - chemistry , emetine , carbodiimide , glycine , stereochemistry , peptide , combinatorial chemistry , organic chemistry , amino acid , biochemistry , medicine , pharmacology
Synthesis of the alkaloidal peptides corresponding to structures Ib–Il has been studied. Of several peptide bond forming techniques, the mixed carbonic anhydride and 1-ethyl-3-(3′-dimethylaminopropyl)carbodiimide methods proved generally useful. The potential utility of emetine as a means of transporting N-bis(2-chloroethyl)glycine is discussed.
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