SYNTHESIS OF SOME ALKYLATED ADENINES AS POTENTIAL ANTIMETABOLITES | Zendy

C. J. Abshire | Zendy; Louis Berlinguet | Zendy

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SYNTHESIS OF SOME ALKYLATED ADENINES AS POTENTIAL ANTIMETABOLITES

Author(s) -

C. J. Abshire,

Louis Berlinguet

Publication year - 1964

Publication title -

canadian journal of chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.323

H-Index - 68

eISSN - 1480-3291

pISSN - 0008-4042

DOI - 10.1139/v64-243

Subject(s) - chemistry , bromide , alkylation , allyl bromide , halide , chloride , dimethylformamide , allyl chloride , medicinal chemistry , benzene , benzyl bromide , organic chemistry , benzyl chloride , magnesium bromide , catalysis , magnesium , solvent

Several substituted adenines and (or) their salts have been prepared by condensing adenine in dimethylformamide with the following halides: benzyl chloride, p-methylbenzyl chloride, n-propyl bromide, (3-chloropropyl) benzene, α-bromo-γ-butyrolactone, allyl bromide, and cinnamyl chloride. The reaction may be carried out in large quantities and the salts were isolated in high yields.Characterization of these compounds indicated that they are pure 3-substituted adenines with the possible exception of the allyl and the n-propyl derivatives, which may contain little, if any, of the 7- or 9-isomers.

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