Open AccessPOTENTIAL CYTOSTATIC CARBOHYDRATE DERIVATIVES: PART II. N-MUSTARD PHOSPHATES
Author(s) -
K. Vagi,
V. W. Adamkiewicz,
Thomas Nogrady
Publication year - 1962
Publication title -
canadian journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.323
H-Index - 68
eISSN - 1480-3291
pISSN - 0008-4042
DOI - 10.1139/v62-160
Subject(s) - phosphoramidate , chemistry , carbohydrate , medicinal chemistry , stereochemistry , organic chemistry
2,3,4,6-Tetra-O-acetyl-D-glucosyl-(N-bis-β-chloroethyl)-phosphoramidate and ethyl-D-fructopyranoside-1-(N-bis-β-chloroethyl)-phosphoramidate have been synthesized. The first compound inhibited Adenocarcinoma 755 to 40–50%.
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