Myocardial homing of mesenchymal stem cells following intrapericardial application and amplification by inflammation — an experimental pilot study | Zendy

Nina Jung | Zendy; Heinz Rupp | Zendy; A. Rembert Koczulla | Zendy; Claus Vogelmeier | Zendy; Peter Alter | Zendy

Open Access

Myocardial homing of mesenchymal stem cells following intrapericardial application and amplification by inflammation — an experimental pilot study

Author(s) -

Nina Jung,

Heinz Rupp,

A. Rembert Koczulla,

Claus Vogelmeier,

Peter Alter

Publication year - 2017

Publication title -

canadian journal of physiology and pharmacology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.559

H-Index - 84

eISSN - 1205-7541

pISSN - 0008-4212

DOI - 10.1139/cjpp-2016-0373

Subject(s) - homing (biology) , mesenchymal stem cell , stem cell , inflammation , pericardium , medicine , cardiac function curve , pathology , cardiology , heart failure , microbiology and biotechnology , immunology , biology , ecology

Recent studies demonstrated potential effects of stem cells on cardiac function in heart failure. However, influences of the technique of application remained undetermined. In the present study, the pericardial sac was used as depot for fluorescent-labeled mesenchymal stem cells in rats. To evaluate influences of inflammation on cell homing, a sterile pericarditis was induced by talc. It is shown that intrapericardial stem cell application is sufficient to provide myocardial penetration. The extent of homing was amplified by inflammation in a talc-induced pericarditis.

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