z-logo
open-access-imgOpen Access
Dynamical Behaviors of the Tumor-Immune System in a Stochastic Environment
Author(s) -
Xiaoyue Li,
Guoting Song,
Yang Xia,
Chenggui Yuan
Publication year - 2019
Publication title -
siam journal on applied mathematics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.954
H-Index - 99
eISSN - 1095-712X
pISSN - 0036-1399
DOI - 10.1137/19m1243580
Subject(s) - uniqueness , ergodicity , mathematics , stationary distribution , lyapunov function , stochastic differential equation , dynamical systems theory , mathematical analysis , exponential stability , statistical physics , markov chain , nonlinear system , physics , statistics , quantum mechanics
This paper investigates dynamic behaviors of the tumor-immune system perturbed by environmental noise. The model describes the response of the cytotoxic T lymphocyte (CTL) to the growth of an immunogenic tumour. The main methods are stochastic Lyapunov analysis, comparison theorem for stochastic differential equations (SDEs) and strong ergodicity theorem. Firstly, we prove the existence and uniqueness of the global positive solution for the tumor-immune system. Then we go a further step to study the boundaries of moments for tumor cells and effector cells and the asymptotic behavior in the boundary equilibrium points. Furthermore, we discuss the existence and uniqueness of stationary distribution and stochastic permanence of the tumor-immune system. Finally, we give several examples and numerical simulations to verify our results.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.
Having issues? You can contact us here
Accelerating Research

Address

John Eccles House
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom