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If an expectant mother develops a splenic artery aneurysm that ruptures, there is a 90% fetal mortality rate. Splenic artery aneurysms account for 46-60% of visceral aneurysms in the human abdomen. The cause for the propensity of aneurysms to develop and rupture along the splenic artery is unknown. A distinguishing characteristic of this artery is its tortuous shape. We investigate how the unique geometries of the artery may lead to unusual patterns in blood flow. Dramatic changes in blood flow properties such as blood pressure, velocity and wall shear are conducive for aneurysm formation, development, and rupture. Using Ansys Fluent computational fluid dynamics software, the influence of these elements of blood flow through both straight and curved arteries is explored. Under identical initial and boundary conditions, the curved artery reaches both higher dynamic pressure and wall shear stress values than the straight artery. The curved artery also has a greater range of dynamic pressure and wall shear stress values compared to the range of values in the straight artery. Additionally, blood flow changes associated with pregnancy, including increased peak velocity, are shown to increase the risk of aneurysm development and rupture. These results indicate that the curved geometry of the splenic artery predisposes it to promote aneurysm rupture and growth.

Exploring Blood Flow Dynamics Underlying Pathogenesis of Splenic Artery Aneurysms