Glucagonoma without cutaneous manifestations | Zendy

J. H. Parr | Zendy; I D Ramsay | Zendy; P. W. N. Keeling | Zendy; R. P. H. Thompson | Zendy; C N Mallinson | Zendy

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Glucagonoma without cutaneous manifestations

Author(s) -

J. H. Parr,

I D Ramsay,

P. W. N. Keeling,

R. P. H. Thompson,

C N Mallinson

Publication year - 1985

Publication title -

postgraduate medical journal

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.568

H-Index - 99

eISSN - 1469-0756

pISSN - 0032-5473

DOI - 10.1136/pgmj.61.718.737

Subject(s) - glucagonoma , medicine , glucagon , diabetes mellitus , erythema , zinc deficiency (plant disorder) , pathology , dermatology , endocrinology , insulin , micronutrient

A 63 year old man presented with features of the glucagonoma syndrome, that is thromboembolic disease, weight loss, raised sedimentation rate, diabetes mellitus, hypoproteinaemia and reduced plasma amino acid levels, but without necrolytic migratory erythema. The plasma glucagon level was raised and the tumour was demonstrated by abdominal CT scan. Immunofluorescent studies of the resected tumour confirmed the diagnosis. The normal tissue zinc status supports the view that necrolytic migratory erythema is related to zinc deficiency.

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