Simvastatin-induced bilateral leg compartment syndrome and myonecrosis associated with hypothyroidism | Zendy

Michael J. Ramdass | Zendy; Gurpreet Singh | Zendy; Brian S. Andrews | Zendy

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Simvastatin-induced bilateral leg compartment syndrome and myonecrosis associated with hypothyroidism

Author(s) -

Michael J. Ramdass,

Gurpreet Singh,

Brian S. Andrews

Publication year - 2007

Publication title -

postgraduate medical journal

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.568

H-Index - 99

eISSN - 1469-0756

pISSN - 0032-5473

DOI - 10.1136/pgmj.2006.051334

Subject(s) - medicine , simvastatin , hydroxymethylglutaryl coa reductase inhibitors , compartment (ship) , bioinformatics , surgery , statin , oceanography , geology , biology

A 54-year-old hypothyroid male taking thyroxine and simvastatin presented with bilateral leg compartment syndrome and myonecrosis. Urgent fasciotomies were performed and the patient made an uneventful recovery with the withdrawal of simvastatin. It is likely that this complication will be seen more often with the increased worldwide use of this drug and its approval for all arteriopathic patients.

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